College Football 2025: Early Odds Highlight Notre Dame, Ohio State, and Transfer-Fueled LSU

Early betting lines for the 2025 college football season place Notre Dame, Ohio State, and Texas as co-favorites to capture the national championship, with odds of +700 at the Westgate SuperBook. Indiana and Oregon trail closely at +800, while Georgia stands at 10-1. LSU, bolstered by a significant influx of 40 transfer players under new coach Lane Kiffin, is listed at 14-1.

The updated odds reflect ongoing investor interest as a number of high-profile programs reshape their rosters through the transfer portal. LSU's acquisition of quarterback Sam Leavitt from Arizona State reportedly involved a deal with a value of approximately $5.5 million.

Ohio State returns quarterback Julian Sayin and holds a projected win total of 9.5 at FanDuel, with betting on the over favored at -158. Sayin also appears among the top Heisman Trophy contenders at 11-1 according to BetMGM. Indiana and Miami each carry FanDuel-projected 10.5 win totals, with Indiana at +700 to win the title and Miami at 10-1. Texas Tech, another program with strong expectations, holds a 14-1 championship line and an 11.5-win total projection.

Oklahoma, currently listed at 40-1 for the national title and 7.5 expected wins, welcomes transfer quarterback John Mateer. The Sooners have added key offensive talent, including receiver Trell Harris from Virginia and returning favorite target Isaiah Sategna. Oklahoma faces a challenging September schedule with away games at Michigan and Georgia, but avoids clashes with Alabama and LSU during the regular season.

Other notable teams include Ole Miss (40-1), led by returning quarterback Trinidad Chambliss—who threw for 3,937 yards last season—and Utah, whose quarterback Devon Dampier is recognized for surpassing 2,000 passing yards and 835 rushing yards in 2024.

Among professional bettors, skepticism surrounds programs such as Rutgers and Wisconsin, with some citing difficult schedules and recent performance trends. Analysts project Rutgers for three or four wins and question Wisconsin’s ability to surpass 6.5 victories as head coach Luke Fickell enters his fourth season with the Badgers.

As momentum builds toward the season, attention remains fixed on final roster moves, preseason rankings, and the national title game scheduled to be played January 25, 2027, at Allegiant Stadium in Las Vegas. Betting lines are subject to adjustment as rosters and schedules evolve ahead of kickoff.